E.S. Issachar is the E.S. that Pellegri pilots, manufactured by Hyams Group. It appears as a boss in Episode II at the Ormus Stronghold, and a boss in Episode III on Michtam. It also appears in Xenosaga: The Animation, where it is revealed Pellegri can Encephalon dive in Issachar while Issachar auto-pilots itself.
It was primarily built for multiple simultaneous multi-directional Ether attacks, making it one of the most air-combat capable Ormus units. The Ether connection base can also be operated as a flexible shield. It is equipped with a spear for close-range defense.
- One of Issachar's attacks is Mal'ach Laser. This probably means "malakh", which is "angel" in Hebrew.