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|“|| Yes... I checked it out... There is no mistake, it's a contact. My child's name is... 'Fei'. So... you understand what this means?
It is implied Karen was born in Shevat, and she was the Nisan Orthodox postulant. This means she wasn't the Holy Mother of Nisan, but was simply a candidate. It is unknown if Karen's Pendant of Nisan is the same one Sophia had hundreds of years ago (if it is, it may have survived the Excalibur's crash - although there's no proof Sophia wore the pendant during the crash), or merely a recreation.
She met Khan Wong when he worked as a lieutenant in Shevat, eventually giving birth to Fei.
When Fei was a little boy, Karen used to play with him by bouncing a ball back and forth. This is one of Fei's childhood memories that survived after his amnesia, so it's a precious memory of her.
Karen was possessed by Myyah, thus transforming herself in Myyah 0997. Upon discovering Fei as the Contact incarnation, Myyah uses her new position to conduct torturous experiments on Fei while his father is away, eventually resulting in the inadvertent creation of Id. Taking Fei to testing labs, Myyah would bring in humans and demi-humans who had a high compatibility with the Anima Relics, to make psychic contact with Fei to forcefully awaken him, causing much psychological damage on Fei's psyche in the process.
10 months after Myyah awakened in Karen, she stands by passively while Grahf, having arrived to take Fei, attacks Khan, triggering a spontaneous release of Fei's power. Karen regains control momentarily, long enough to throw herself in front of her son to save his life, and is mortally wounded in the process.
Karen's pendant, which was the Pendant of Nisan, was given to Fei, and Fei subsequently gave it to Elly Van Houten, a reincarnation of Sophia.
The name "Karen" means pure. This could be a reference to how Karen was "pure" in Fei's eyes, or how a mother's purity is contaminated by Myyah.